Durable response to dual immune checkpoint blockade in Lynch syndrome–associated serous ovarian carcinoma: a case report
Mohamad Mourad, Nada Assaf, Layal Al Mahmasani, Rami Mahfouz, Najla Fakhruddin, Ali Shamseddine · 2026
Read Durable response to dual immune checkpoint blockade in Lynch syndrome–associated serous ovarian carcinoma: a case report by Mohamad Mourad, Nada Assaf, Layal Al Mahmasani, Rami Mahfouz, Najla Fakhruddin, Ali Shamseddine (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13574704.txt.
Description
Mohamad Mourad and five colleagues report a striking case of ovarian cancer that melted away under immune therapy alone. Their patient, a woman of forty-two, had high-grade serous cancer spread to liver, belly lining, lymph nodes, and bone. Testing showed her tumor lacked a DNA repair protein, and she carried a Lynch syndrome mutation in MSH2.
Doctors advised chemotherapy plus immune drugs, but she refused chemo. She received two checkpoint blockers together instead. Scans soon showed near-total clearing of disease. Surgery found only minimal leftovers. Two years later she stayed in full remission on maintenance treatment. The case argues for gene testing to guide such choices.
Catalog record
| CREATOR | Mohamad Mourad, Nada Assaf, Layal Al Mahmasani, Rami Mahfouz, Najla Fakhruddin, Ali Shamseddine |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |