Molecular characterization of a novel Trichinella spiralis aspartyl protease and its role in the larval invasion of host intestinal epithelial cells
Yao Zhang, Ru Zhang, Xin Zhuo Zhang, Shao Rong Long, Xi Zhang, Ruo Dan Liu, Zhong Quan Wang, Jing Cui · 2026
Read Molecular characterization of a novel Trichinella spiralis aspartyl protease and its role in the larval invasion of host intestinal epithelial cells by Yao Zhang, Ru Zhang, Xin Zhuo Zhang, Shao Rong Long, Xi Zhang, Ruo Dan Liu, Zhong Quan Wang, Jing Cui (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13574316.txt.
Description
A worm enzyme that helps larvae breach gut walls is profiled by Yao Zhang and co-authors in work dated 2026. The worm, Trichinella spiralis, lives in meat and invades the gut on entry. Its aspartyl protease was cloned and built in the lab. Mice given the protein raised strong antibody replies. Gene reads showed the enzyme on at all life stages, loudest in gut forms.
Stains put it on the worm's skin and in adult females. The protein sticks to gut cells, chiefly at their surface. Added protein sped larva entry into gut cell sheets. Blocking it slowed entry, a drug lead.
Catalog record
| CREATOR | Yao Zhang, Ru Zhang, Xin Zhuo Zhang, Shao Rong Long, Xi Zhang, Ruo Dan Liu, Zhong Quan Wang, Jing Cui |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |