Glioblastoma recurrence: An NGS-centered seed-soil framework
Jun-yi Xu, Jingxian Chen, Wenyan Feng, Guo-zhong Yi · 2026
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Description
Jun-yi Xu and three co-authors set out a new frame for why a severe brain tumor comes back after surgery, in a 2026 paper. The tumor type they study almost always returns. Past models stress traits inside the tumor cells alone. The authors argue that view misses how left-behind cells rebuild disease with help from nearby brain tissue.
They cast left-behind tumor cells as seeds and the post-surgery brain as soil. Links between nerve cells and tumor cells form the meeting point of seed and soil. The paper tracks how treatment may reshape those links and aid spread near or far from the cut site. The authors mark clearly what is proven and what is still a guess. They call for long-term models after surgery and for tests that block those links.
Catalog record
| CREATOR | Jun-yi Xu, Jingxian Chen, Wenyan Feng, Guo-zhong Yi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |