Disruption of prefrontal and superior temporal gyrus white matter networks in antipsychotic-treated schizophrenia with comorbid metabolic syndrome
Ying Li, Qianqian Liu, Xinyue Chen, Shiji Peng, Hangyu Li, Kaike Liao, Rui Yu, Nian Liu · 2026
Read Disruption of prefrontal and superior temporal gyrus white matter networks in antipsychotic-treated schizophrenia with comorbid metabolic syndrome by Ying Li, Qianqian Liu, Xinyue Chen, Shiji Peng, Hangyu Li, Kaike Liao, Rui Yu, Nian Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13573662.txt.
Description
Ying Li and seven co-authors wrote this 2026 study on brain wiring in schizophrenia patients who also have metabolic syndrome. The syndrome, a cluster of weight, sugar, and fat problems, is common in people taking antipsychotic drugs. The team scanned three groups: patients with the syndrome, patients without it, and healthy controls, then mapped each person's white matter network.
Both patient groups showed weaker links across frontal, parietal, and temporal regions than controls. Patients with the syndrome lost more frontal connectivity still, and their network hubs in the frontal lobe and a hearing-related region worked less efficiently. Those network measures tracked body weight, waist size, blood sugar, and fat levels. One region's weakness may even sit on the path from the combined illness to higher weight. The scans give a brain-level clue to a common drug side effect.
Catalog record
| CREATOR | Ying Li, Qianqian Liu, Xinyue Chen, Shiji Peng, Hangyu Li, Kaike Liao, Rui Yu, Nian Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |