Pre-operative circulating tumour DNA in high-risk primary cutaneous melanoma: prospective feasibility in molecular pathology
Magnús Pétur Bjarnason Obinah, Estrid Høgdall, Tim Svenstrup Poulsen, Karin Dreisig, Thomas Litman, Christoffer Johansen, Stig Egil Bojesen, Lisbet Rosenkrantz Hölmich · 2026
Read Pre-operative circulating tumour DNA in high-risk primary cutaneous melanoma: prospective feasibility in molecular pathology by Magnús Pétur Bjarnason Obinah, Estrid Høgdall, Tim Svenstrup Poulsen, Karin Dreisig, Thomas Litman, Christoffer Johansen, Stig Egil Bojesen, Lisbet Rosenkrantz Hölmich (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13573568.txt.
Description
Magnús Pétur Bjarnason Obinah and co-authors test whether tumor DNA floating in blood can be caught before surgery in high-risk skin melanoma. Such circulating tumor DNA is a promising warning marker, but tiny primary tumors may shed too little to detect. The team ran a prospective study at one center using tools a normal pathology lab already has.
Of 288 patients who gave blood before surgery, twenty-one had confirmed high-risk melanoma, and twelve carried a known driver mutation that a blood test could target. The blood test found tumor DNA in none of those twelve patients. Control checks confirmed the assays themselves worked properly. The authors note the blank result matches two other studies and a math prediction of how little DNA small tumors shed.
Catalog record
| CREATOR | Magnús Pétur Bjarnason Obinah, Estrid Høgdall, Tim Svenstrup Poulsen, Karin Dreisig, Thomas Litman, Christoffer Johansen, Stig Egil Bojesen, Lisbet Rosenkrantz Hölmich |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 21 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |