Rational design of an optimized ferritin nanoparticle vaccine targeting both SARS-CoV-2 and MERS-CoV
Yaoming Liu, Haiyue Rao, Nana Wang, Xiaoqing Liu, Tao Chen, Bin Zhang, Jintao Lai, Jianyu Shan, Shiqi Xiao, Haojie Peng, Yiqiang Zhu, Taizhen Liang, Sen Liu, Meilin Hu, Lixiang Xie, Guochang Qiu, Xiaobo Li, Yaxin Li, Xiancai Ma · 2026
Read Rational design of an optimized ferritin nanoparticle vaccine targeting both SARS-CoV-2 and MERS-CoV by Yaoming Liu, Haiyue Rao, Nana Wang, Xiaoqing Liu, Tao Chen, Bin Zhang, Jintao Lai, Jianyu Shan, Shiqi Xiao, Haojie Peng, Yiqiang Zhu, Taizhen Liang, Sen Liu, Meilin Hu, Lixiang Xie, Guochang Qiu, Xiaobo Li, Yaxin Li, Xiancai Ma (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13573459.txt.
Description
Yaoming Liu, with 18 colleagues, presents a 2026 design for a two-in-one coronavirus vaccine built on ferritin cages. Ferritin, an iron-storing protein, forms tiny cages that can display virus parts on their surface. Past cages were unstable and uneven, which blocked large-scale making and long storage.
Guided by AI modelling, the team added a sulfur bond across cage subunits. Sharp imaging confirmed the bond, and the new cage held up better to heat and acid, with cleaner, more even particles. A glue system then fixed the binding tips of both SARS-CoV-2 and MERS-CoV onto the cages. In mice, the paired vaccine raised stronger antibody and T cell responses than single versions. Two doses guarded engineered mice against live challenge with both viruses. No body-wide harm appeared.
Catalog record
| CREATOR | Yaoming Liu, Haiyue Rao, Nana Wang, Xiaoqing Liu, Tao Chen, Bin Zhang, Jintao Lai, Jianyu Shan, Shiqi Xiao, Haojie Peng, Yiqiang Zhu, Taizhen Liang, Sen Liu, Meilin Hu, Lixiang Xie, Guochang Qiu, Xiaobo Li, Yaxin Li, Xiancai Ma |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 154173 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |