Effect of empagliflozin with or without carvedilol on tricuspid regurgitation and right ventricular remodeling: PROVE trial
Ga Yun Kim, So-Min Lim, Dong Hyun Yang, Jong Eun Lee, Sahmin Lee, Sung-Ji Park, In-Chang Hwang, Yeonyee Elizabeth Yoon, Chi Young Shim, Hyung-Kwan Kim, Sung-Cheol Yun, Jong-Min Song, Duk-Hyun Kang · 2026
Read Effect of empagliflozin with or without carvedilol on tricuspid regurgitation and right ventricular remodeling: PROVE trial by Ga Yun Kim, So-Min Lim, Dong Hyun Yang, Jong Eun Lee, Sahmin Lee, Sung-Ji Park, In-Chang Hwang, Yeonyee Elizabeth Yoon, Chi Young Shim, Hyung-Kwan Kim, Sung-Cheol Yun, Jong-Min Song, Duk-Hyun Kang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13573426.txt.
Description
Ga Yun Kim and a large team run a randomized trial, called PROVE, on leaky heart valves and a strained right heart in a 2026 study. The leak sits in the tricuspid valve and worsens as the right chamber stretches, in a vicious cycle tied to poor outcomes. Drugs that help the chamber shrink back could break that cycle.
Fifty-six patients with a strong functional leak were split into four arms in a two-by-two design. The arms paired a diabetes drug, empagliflozin, and a heart drug, carvedilol, alone, together, or with placebos. The main score was change in a right-chamber volume index over 12 months. Secondary scores covered other chamber volumes and pumping strength. The four-way split lets the team judge each drug and their pairing at once.
Catalog record
| CREATOR | Ga Yun Kim, So-Min Lim, Dong Hyun Yang, Jong Eun Lee, Sahmin Lee, Sung-Ji Park, In-Chang Hwang, Yeonyee Elizabeth Yoon, Chi Young Shim, Hyung-Kwan Kim, Sung-Cheol Yun, Jong-Min Song, Duk-Hyun Kang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |