Spatiotemporal genomic analysis and risk assessment of the plasmids carrying blaOXA-48-like genes based on a large-scale international dataset
Qiheng Yuan, Junlin Wang, Xiaowei Liu, Xumeng Yu, Jiatao Li, Du Guo, Qinru Jing, Yongliang Lou, Yutong Kang, Meiqin Zheng · 2026
Read Spatiotemporal genomic analysis and risk assessment of the plasmids carrying blaOXA-48-like genes based on a large-scale international dataset by Qiheng Yuan, Junlin Wang, Xiaowei Liu, Xumeng Yu, Jiatao Li, Du Guo, Qinru Jing, Yongliang Lou, Yutong Kang, Meiqin Zheng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13573423.txt.
Description
Qiheng Yuan, with nine colleagues, reports a 2026 gene study of plasmids that carry drug resistance across borders. These small DNA rings hold genes for OXA-48-like enzymes, which break last-resort antibiotics called carbapenems. Tracking the rings, not just the bacteria, shows how resistance hops between species and places.
The team mined 747 complete plasmid sequences from a public database, the largest such set yet. The rings turned up in 50 countries on six continents, with one gene form leading in Europe and others in South Asia. Sixteen spread units were defined, and one traced to the Netherlands around 2005 before fanning out worldwide. Rings often carried extra resistance to other drug families at once. High-risk forms showed up in non-clinical settings too, which widens the watch list for health teams.
Catalog record
| CREATOR | Qiheng Yuan, Junlin Wang, Xiaowei Liu, Xumeng Yu, Jiatao Li, Du Guo, Qinru Jing, Yongliang Lou, Yutong Kang, Meiqin Zheng |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56900 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |