Cofilin/RhoA and CREB synergistically promote invasion and migration of polyploid giant cancer cells in colorectal cancer
Yidi Ning, Kai Liu, Jing Xu, Liechen Ji, Shiwu Zhang · 2026
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Description
Yidi Ning, Kai Liu, Jing Xu, Liechen Ji, and Shiwu Zhang published a study in 2026 on giant multi-nucleus cancer cells in colorectal cancer. These polyploid giant cells help tumors start and spread. The team grew them from two cell lines with a chemical trigger; the giants and their daughters moved and invaded more aggressively. A shape-control protein, cofilin, ran high in the daughters.
A small tag on cofilin, placed by a partner protein, sent it into the nucleus and kept it from destruction. Nuclear cofilin raised a second protein's production, which in turn boosted a factor that feeds back onto cofilin's own gene. Silencing cofilin shrank tumors in mice. The authors propose the loop as a treatment target.
Catalog record
| CREATOR | Yidi Ning, Kai Liu, Jing Xu, Liechen Ji, Shiwu Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |