Smoking-Associated Enrichment of CXCL13+ Tfh Cells and VCAM1+ Fibroblasts Is Linked to Tertiary Lymphoid Structure Formation in Lung Adenocarcinoma
Yong Jun Choi, Chi Young Kim, Eun Young Kim, Sang Hoon Lee, Min Kyung Park, Yoon Soo Chang · 2026
Read Smoking-Associated Enrichment of CXCL13+ Tfh Cells and VCAM1+ Fibroblasts Is Linked to Tertiary Lymphoid Structure Formation in Lung Adenocarcinoma by Yong Jun Choi, Chi Young Kim, Eun Young Kim, Sang Hoon Lee, Min Kyung Park, Yoon Soo Chang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13573297.txt.
Description
Yong Jun Choi and five co-authors compared the tumor surroundings of lung cancer in smokers and never-smokers, in a 2026 study. Smokers often respond better to immune therapy for this cancer, for reasons that are not fully clear. The team looked for cell patterns tied to small lymph-like clusters that can form inside tumors.
They merged single-cell data from tumors and nearby tissue of five current smokers and five never-smokers. Helper T cells that call in B cells were richer in smokers, while resident memory T cells were fewer. Stained tissue confirmed far more of the calling cells in smokers, and their density tracked with B cell density. Smokers also carried more of the lymph-like clusters. The authors link the cell pattern to cluster growth and propose it as a marker for further study.
Catalog record
| CREATOR | Yong Jun Choi, Chi Young Kim, Eun Young Kim, Sang Hoon Lee, Min Kyung Park, Yoon Soo Chang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |