Phosphoinositides and inositol phosphates as molecular glues
Aleshia Seaton‐Terry, Alexander J Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W Gilligan, Jakub N Kubina, Michael J Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D Blind · 2026
Read Phosphoinositides and inositol phosphates as molecular glues by Aleshia Seaton‐Terry, Alexander J Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W Gilligan, Jakub N Kubina, Michael J Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D Blind (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13573059.txt.
Description
Aleshia Seaton-Terry, with nine colleagues, reviews 2026 work on small cell molecules that can act as glue between proteins. The molecules, inositol phosphates and their lipid cousins, carry dense negative charge. Some sit in membranes and call proteins over; others float free and lock inside protein cores.
Recent structure studies show these molecules wedged at the seam where two proteins meet, holding the pair together. The review sorts cases by how firm the glue claim is, from proven seams to pairs that await sharp structural proof. Cases span signal proteins, gene control parts, and membrane receptors. The authors argue the glue role has been under-rated and call for a systematic structural hunt. Such a hunt could seed new drugs that work by sticking proteins together on purpose.
Catalog record
| CREATOR | Aleshia Seaton‐Terry, Alexander J Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W Gilligan, Jakub N Kubina, Michael J Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D Blind |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39424 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |