Advances in Spatial Heterogeneity and Cellular Localization Specificity of Intratumoral Bacteria

Minlan Ren, Jing Jia, Tingting Li, Yiwei Li, Nanxiang Shen, Yun Shi, Zhe Wang, Hao Fan, Guangli Sun, Guanying Xiong, Gang Li, Rui Peng · 2026

Read Advances in Spatial Heterogeneity and Cellular Localization Specificity of Intratumoral Bacteria by Minlan Ren, Jing Jia, Tingting Li, Yiwei Li, Nanxiang Shen, Yun Shi, Zhe Wang, Hao Fan, Guangli Sun, Guanying Xiong, Gang Li, Rui Peng (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13572861.txt.

Description

Minlan Ren and eleven co-authors review the bacteria that live inside tumors in a 2026 paper. Where a microbe sits in a tumor, and how many there are, shapes what it does. The authors compare detection methods and sort the evidence into three patterns: organized communities in tissue, bacteria inside cells, and bacteria free between cells.

Each pattern links differently to signaling, metabolism, spread, drug resistance, and immune response. The review is strict about method: tumor samples carry so few microbes that contamination, batch effects, and missing controls can fake findings. It separates patient observations from lab mechanisms and grades the clinical proof. The authors see spatial microbiology as promising but not yet clinic-ready.

Catalog record

CREATORMinlan Ren, Jing Jia, Tingting Li, Yiwei Li, Nanxiang Shen, Yun Shi, Zhe Wang, Hao Fan, Guangli Sun, Guanying Xiong, Gang Li, Rui Peng
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE59 KB
VERSION1.0
LICENSECC BY 4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/articles/PMC13572861

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