Carrier‐Free Stimulus‐Responsive Theranostic Nanoprodrug Enabling GSH‐Consumption‐Promoted Chemo‐Photodynamic Cancer Therapy
Hansheng Huang, Binglin Sui · 2026
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Description
Hansheng Huang and Binglin Sui designed a nanoprodrug that pairs chemotherapy with light-activated therapy against cancer. Combining the two treatments works better than either alone, they note. Cancer cells use glutathione to resist drugs and neutralize reactive oxygen species. Their twenty twenty-six design turns that defense into a trigger. The particle links paclitaxel to a light-sensitive dye through a bond that glutathione breaks.
The carrier-free particles measure about sixty-five nanometers across and are over seventy percent drug by content. A control version used a bond that glutathione cannot break. Under light, the responsive particles suppressed tumor growth more strongly than free paclitaxel. Consuming glutathione while releasing the drug deepens the combined attack. The design also carries imaging capability, making it a combined treatment and diagnostic agent.
Catalog record
| CREATOR | Hansheng Huang, Binglin Sui |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |