TGF-β-producing tBregs are associated with poor survival rates in PTGS2-high cancers
Kavitha Premkumar, Soundharya Ramu, Mohit Kumar Jolly, Bhavani S. Shankar · 2026
Read TGF-β-producing tBregs are associated with poor survival rates in PTGS2-high cancers by Kavitha Premkumar, Soundharya Ramu, Mohit Kumar Jolly, Bhavani S. Shankar (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13572553.txt.
Description
Kavitha Premkumar, with three colleagues, ran a 2026 study of immune cells that help tumours by calming other immune cells. These regulatory B cells make a signal, TGF-β, that mutes T cell attack. What pushes B cells into that role inside a tumour was not known.
In mouse fibrosarcoma, removing these B cells slowed tumour growth, and putting B cells back restored it. A fat-like signal from the tumour, PGE2, drove their formation through a STAT3 route. Only the TGF-β-making subset truly suppressed T cells. A COX-2 blocker stopped their formation, shrank tumours, and freed T cell responses. In human data, cancers high in the PGE2-making gene PTGS2 carried the same B cell pattern and worse survival. The authors propose blocking that route in care.
Catalog record
| CREATOR | Kavitha Premkumar, Soundharya Ramu, Mohit Kumar Jolly, Bhavani S. Shankar |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82215 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |