Bone aging: a paradigm of multiscale degeneration and targeted rejuvenation
Kangpeng Li, Chenyuan Gao, Ti Zhang, Cheng Wang, Xiao Geng, Xinguang Wang, Hua Tian · 2026
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Description
Kangpeng Li and six co-authors review bone aging as a failure that unfolds at many scales at once. Their 2026 review stresses that aging bone is not just bone lost. At the whole-bone level, mass, fine structure, and strength all decline until fractures come easily. Below that surface sit layers of change in molecules, cells, the local environment, and the body's hormone systems.
The review walks those layers in turn: gene and epigenetic shifts, oxidative stress, worn telomeres, failing mitochondria, chronic inflammation, and the remodeling of the matrix that holds bone together. Against them it sets the current arsenal, from diet and exercise to drugs that slow breakdown or build bone, plus newer ideas such as senolytics, gene therapy, and tissue engineering. The authors look ahead to a multi-omics atlas of bone aging, organ-like bone models, and prevention-first public health.
Catalog record
| CREATOR | Kangpeng Li, Chenyuan Gao, Ti Zhang, Cheng Wang, Xiao Geng, Xinguang Wang, Hua Tian |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 89 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |