NRP1 promotes hepatic fibrosis by regulating Src/Rab7-mediated lysosomal degradation of TβRI
Zhe Jia, Xiaodong Song, Jie Bai · 2026
Read NRP1 promotes hepatic fibrosis by regulating Src/Rab7-mediated lysosomal degradation of TβRI by Zhe Jia, Xiaodong Song, Jie Bai (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13572504.txt.
Description
Zhe Jia, with two colleagues, describes a 2026 study of liver scarring and a helper protein that keeps a growth signal alive. Liver fibrosis builds when stellate cells switch on and pour out matrix under a signal called TGF-β. The helper, neuropilin-1, rises in those switched-on cells, yet how it guards the signal's receptor was unclear.
Silencing the helper in mouse stellate cells cut receptor protein levels while its gene message stayed flat. The receptor instead moved faster to lysosomes, the cell's disposal sacs, for breakdown. A chain through two partners, Src and Rab7, explains the shift: loss of the helper raised active Rab7 and sped sorting into late transport sacs. In mice, silencing the helper eased toxin-driven scarring and lowered receptor levels. Blocking Rab7 partly undid those gains, which backs the chain.
Catalog record
| CREATOR | Zhe Jia, Xiaodong Song, Jie Bai |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44791 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |