Enhancing iNKT cell immunotherapy through the integration of optimized CAR endodomains and iNKT engagers
Kanagaraju Ponnusamy, Klesti Karaxhuku, Yuchao Jiang, Lyra Randzavola, Hongwei Ren, Ilia Leontari, Bryan Lye, Mehmood Zaidi, Edward J Bartlett, Edward W Tate, Vasileios Pardalis, Dimitrios Leonardos, Reza Nadafi, Irene Sarkar, Rogier M Reijmers, Marco Bua, Maria Atta, Alexia Katsarou, Irene AG Rober · 2026
Read Enhancing iNKT cell immunotherapy through the integration of optimized CAR endodomains and iNKT engagers by Kanagaraju Ponnusamy, Klesti Karaxhuku, Yuchao Jiang, Lyra Randzavola, Hongwei Ren, Ilia Leontari, Bryan Lye, Mehmood Zaidi, Edward J Bartlett, Edward W Tate, Vasileios Pardalis, Dimitrios Leonardos, Reza Nadafi, Irene Sarkar, Rogier M Reijmers, Marco Bua, Maria Atta, Alexia Katsarou, Irene AG Rober (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13572498.txt.
Description
Kanagaraju Ponnusamy and a large team upgrade a cell therapy aimed at multiple myeloma, in a 2026 paper. The therapy uses iNKT cells, a rare immune type that can be shared between donors, fitted with a synthetic receptor that hunts a myeloma marker called BCMA. Five receptor tail designs were compared head to head. One design stood out, helped by a sticking interaction between a protein on the therapy cells and one on myeloma cells.
That design beat even standard CAR-T cells against myeloma in their tests. The team also built a separate engager molecule that drags iNKT cells onto the cancer and boosts them further. Combining tuned receptors with engagers aims at a stronger off-the-shelf therapy for a cancer that often outlasts current drugs.
Catalog record
| CREATOR | Kanagaraju Ponnusamy, Klesti Karaxhuku, Yuchao Jiang, Lyra Randzavola, Hongwei Ren, Ilia Leontari, Bryan Lye, Mehmood Zaidi, Edward J Bartlett, Edward W Tate, Vasileios Pardalis, Dimitrios Leonardos, Reza Nadafi, Irene Sarkar, Rogier M Reijmers, Marco Bua, Maria Atta, Alexia Katsarou, Irene AG Rober |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |