A combined ex vivo fundus imaging–histology protocol for clinicopathological validation of human donor eyes with limited medical history
Sarrvesa H Vijay Singh, Waiwai Yeap, Lay Khoon Too, Alexandra Allende, Geoffrey Hall, Alex Hunyor, Michele C Madigan, Rohan Merani, Juan Ortiz, Michael Rodriguez, James Wong, Alessandro Invernizzi, Murray Killingsworth, Victoria Pye, Hemal Mehta, Constantinos Petsoglou, Svetlana Cherepanoff · 2026
Read A combined ex vivo fundus imaging–histology protocol for clinicopathological validation of human donor eyes with limited medical history by Sarrvesa H Vijay Singh, Waiwai Yeap, Lay Khoon Too, Alexandra Allende, Geoffrey Hall, Alex Hunyor, Michele C Madigan, Rohan Merani, Juan Ortiz, Michael Rodriguez, James Wong, Alessandro Invernizzi, Murray Killingsworth, Victoria Pye, Hemal Mehta, Constantinos Petsoglou, Svetlana Cherepanoff (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13572494.txt.
Description
Sarrvesa H Vijay Singh, with 16 colleagues, carried out a 2026 study of checks on donor eyes used in research. Eye banks supply donor eyes, yet records on the donor's health are often thin, and scans alone may not show what disease is present. The team paired photos and scans of the eye's back with full tissue study under the microscope.
Fifty-one fixed eyes from 32 donors went through the paired workflow. Imaging alone found clear disease in 10 eyes, while tissue study found it in 20 eyes, among them early macular wear, vessel damage from high pressure, and a rare tumour. The two routes agreed in 27 eyes, mostly where no disease was present. Imaging caught just 18.8 percent of diseased eyes and misread several cases. The authors say pairing both routes makes best use of scarce tissue.
Catalog record
| CREATOR | Sarrvesa H Vijay Singh, Waiwai Yeap, Lay Khoon Too, Alexandra Allende, Geoffrey Hall, Alex Hunyor, Michele C Madigan, Rohan Merani, Juan Ortiz, Michael Rodriguez, James Wong, Alessandro Invernizzi, Murray Killingsworth, Victoria Pye, Hemal Mehta, Constantinos Petsoglou, Svetlana Cherepanoff |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57862 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |