Psychotropic drug-induced weight gain and untargeted metabolomics: machine learning-driven results from a prospective cohort study
Marianna Piras, Gaëlle Magliocco, Setareh Ranjbar, Sylvain Le Gludic, Marie Gasser, Franziska Gamma, Martin Preisig, Séverine Crettol, Frederik Vandenberghe, Nicolas Ansermot, Carole Grandjean, Céline Dubath, Armin von Gunten, Philippe Conus, Aurelien Thomas, Chin Bin Eap · 2026
Read Psychotropic drug-induced weight gain and untargeted metabolomics: machine learning-driven results from a prospective cohort study by Marianna Piras, Gaëlle Magliocco, Setareh Ranjbar, Sylvain Le Gludic, Marie Gasser, Franziska Gamma, Martin Preisig, Séverine Crettol, Frederik Vandenberghe, Nicolas Ansermot, Carole Grandjean, Céline Dubath, Armin von Gunten, Philippe Conus, Aurelien Thomas, Chin Bin Eap (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13572460.txt.
Description
Marianna Piras, with 15 colleagues, reports a 2026 study of blood chemistry shifts tied to weight gain from mental health drugs. Many such drugs add weight and raise heart risk, but the body changes behind the gain are not well mapped. The team used a broad scan of small molecules in blood plasma, not just a few set markers.
The study drew on a cohort of patients who started a weight-linked drug, with 151 follow-up visits from 135 patients. Blood was drawn at the start and again later, and a strict selection method picked 56 features tied to weight change per month. Ten were named, and six were confirmed against standards. Gains in fat-like molecules and in breakdown products of tryptophan tracked with more weight gain. Two compounds tracked the other way. The named set may seed early warning tests.
Catalog record
| CREATOR | Marianna Piras, Gaëlle Magliocco, Setareh Ranjbar, Sylvain Le Gludic, Marie Gasser, Franziska Gamma, Martin Preisig, Séverine Crettol, Frederik Vandenberghe, Nicolas Ansermot, Carole Grandjean, Céline Dubath, Armin von Gunten, Philippe Conus, Aurelien Thomas, Chin Bin Eap |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46427 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |