Histidine to glutamine substitutants, a regulated process that impacts cell survival and suggests histidine shortage in cancer
Domenica Lovecchio, Pierre-René Körner, Lorenzo Valcanover, Onno B Bleijerveld, Bart R J Blokhuis, Abhijeet Pataskar, Jasmine Montenegro Navarro, Demi Wernaart, Liesbeth Hoekman, Daniil Anastasopoulos, Kim Vrijland, Xiaodong Feng, Julien Champagne, Karin E de Visser, Olaf van Tellingen, Frank A Redegeld, Reuven Agami · 2026
Read Histidine to glutamine substitutants, a regulated process that impacts cell survival and suggests histidine shortage in cancer by Domenica Lovecchio, Pierre-René Körner, Lorenzo Valcanover, Onno B Bleijerveld, Bart R J Blokhuis, Abhijeet Pataskar, Jasmine Montenegro Navarro, Demi Wernaart, Liesbeth Hoekman, Daniil Anastasopoulos, Kim Vrijland, Xiaodong Feng, Julien Champagne, Karin E de Visser, Olaf van Tellingen, Frank A Redegeld, Reuven Agami (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13572455.txt.
Description
Domenica Lovecchio, with 16 colleagues, reports a 2026 study of a protein-building error that shows up when cancer cells lack histidine. That amino acid is a building block the body must get from food. When it runs short, cells can swap it for a close cousin, glutamine, at the wrong spots in new proteins.
In lab cancer cells starved of histidine, that swap was the strongest such event seen. Scans of cancer protein data found the swap rich in pancreatic, uterine, and kidney cancers. The team links the error to a misaligned transfer RNA, the molecule that carries building blocks to the protein factory. A tweak to that carrier raised the swap rate and changed how well cells survived the shortage. Host proteins kept being made despite the swap, which hints at a managed response, not random damage.
Catalog record
| CREATOR | Domenica Lovecchio, Pierre-René Körner, Lorenzo Valcanover, Onno B Bleijerveld, Bart R J Blokhuis, Abhijeet Pataskar, Jasmine Montenegro Navarro, Demi Wernaart, Liesbeth Hoekman, Daniil Anastasopoulos, Kim Vrijland, Xiaodong Feng, Julien Champagne, Karin E de Visser, Olaf van Tellingen, Frank A Redegeld, Reuven Agami |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 96098 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |