Syringic acid pretreatment potentiates antioxidant mechanism and downregulates inflammatory signaling towards doxorubicin-related oxidoinflammatory hepatorenal damage in rats
Muhammed Talha Karadogan, Yesim Yeni, Bahtinur Yeter, Ali Gungor, Durdu Altuner, Faraz Azade, Cebrail Gursul, Halis Suleyman · 2026
Read Syringic acid pretreatment potentiates antioxidant mechanism and downregulates inflammatory signaling towards doxorubicin-related oxidoinflammatory hepatorenal damage in rats by Muhammed Talha Karadogan, Yesim Yeni, Bahtinur Yeter, Ali Gungor, Durdu Altuner, Faraz Azade, Cebrail Gursul, Halis Suleyman (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13572440.txt.
Description
Muhammed Talha Karadogan, with seven colleagues, reports a 2026 rat study of a plant compound that may shield the liver and kidneys from a cancer drug. The drug, doxorubicin, fights tumours well but harms both organs as the body clears it. The compound, syringic acid, is a natural substance that fights oxidation.
Rats got syringic acid by mouth at 100 milligrams per kilogram for ten days. On day eight, one set got a single shot of doxorubicin at 20 milligrams per kilogram to trigger organ harm. Blood tests tracked liver enzymes, urea, and creatinine, which rise when the organs suffer. Tissue slices from liver and kidney were checked under the microscope, along with a marker of fat damage. The design tests whether pre-treatment can blunt the drug's harm while it does its cancer work.
Catalog record
| CREATOR | Muhammed Talha Karadogan, Yesim Yeni, Bahtinur Yeter, Ali Gungor, Durdu Altuner, Faraz Azade, Cebrail Gursul, Halis Suleyman |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49656 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |