Long-term cross-variant Fc-mediated immune responses against SARS-CoV-2 induced by a heterologous adenoviral/inactivated virus prime-boost vaccination strategy

Doyoung Kim, Jung Hyuk Lee, Junhyeon Lee, Ju Yeon Park, Yuna Shin, Soo Ji Kim, BeomMin Cheon, Sumin Lee, Eunjin Cho, Deok Ryun Kim, Ryan P McNamara, Cheol-Heui Yun, Mohamadou Siribie, Asma Binte Aziz, Birkneh Tilahun Tadesse, Florian Marks, Sue Kyoung Jo, Hyon Jin Jeon, Raphaël Rakotozandrindrainy, · 2026

Read Long-term cross-variant Fc-mediated immune responses against SARS-CoV-2 induced by a heterologous adenoviral/inactivated virus prime-boost vaccination strategy by Doyoung Kim, Jung Hyuk Lee, Junhyeon Lee, Ju Yeon Park, Yuna Shin, Soo Ji Kim, BeomMin Cheon, Sumin Lee, Eunjin Cho, Deok Ryun Kim, Ryan P McNamara, Cheol-Heui Yun, Mohamadou Siribie, Asma Binte Aziz, Birkneh Tilahun Tadesse, Florian Marks, Sue Kyoung Jo, Hyon Jin Jeon, Raphaël Rakotozandrindrainy, (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13572433.txt.

Description

Doyoung Kim and a large team track long antibody action after mixed vaccine schedules, in work from 2026. Short supply blocked same product boosting in many low resource regions during the pandemic. Mixed prime and boost schedules offer a flexible path when stocks vary by site.

Adults in Mozambique and Madagascar took one of four single or mixed schedules. Blood tests mapped antibody tail functions against wild and Omicron virus forms. One mixed order gave broad and lasting responses for up to six months. Killer cell activation stood out as its mark of durable cross variant cover. Responses faded more slowly than with a single dose schedule alone.

Catalog record

CREATORDoyoung Kim, Jung Hyuk Lee, Junhyeon Lee, Ju Yeon Park, Yuna Shin, Soo Ji Kim, BeomMin Cheon, Sumin Lee, Eunjin Cho, Deok Ryun Kim, Ryan P McNamara, Cheol-Heui Yun, Mohamadou Siribie, Asma Binte Aziz, Birkneh Tilahun Tadesse, Florian Marks, Sue Kyoung Jo, Hyon Jin Jeon, Raphaël Rakotozandrindrainy,
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE60 KB
VERSION1.0
LICENSECC BY 4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/articles/PMC13572433

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