Ferroptosis-induced oxidative stress in therapy-resistant glioblastoma
Sofia Remedia, Cristina Martelli, Marcella Bonanomi, Bruno Giovanni Galuzzi, Francesca Servidio, Clarissa Gervasoni, Martina Nespoli, Chiara Pellizzer, Alessandro Giammona, Daniela Gaglio, Daniele Capitanio, Gloria Bertoli, Luisa Ottobrini, Alessia Lo Dico · 2026
Read Ferroptosis-induced oxidative stress in therapy-resistant glioblastoma by Sofia Remedia, Cristina Martelli, Marcella Bonanomi, Bruno Giovanni Galuzzi, Francesca Servidio, Clarissa Gervasoni, Martina Nespoli, Chiara Pellizzer, Alessandro Giammona, Daniela Gaglio, Daniele Capitanio, Gloria Bertoli, Luisa Ottobrini, Alessia Lo Dico (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13572394.txt.
Description
Sofia Remedia, with 13 colleagues, reports a 2026 study of a cell death route that might beat drug resistance in glioblastoma. The standard drug for this brain cancer often stops working. The route in focus, ferroptosis, kills cells through iron and damage to cell fats, a path the resistant cells may not block.
The team treated one drug-sensitive and three drug-resistant glioma cell lines with three compounds that trigger this death route. The compounds cut cell survival and slowed tumours in mice. Resistant cells showed high levels of a stress protein and strong shields against damage. Treatment raised harmful oxygen byproducts, lowered key guard proteins, and cut the stress protein in tumour tissue. Blocking those byproducts in cell powerhouses saved the cells, which points to where the damage starts.
Catalog record
| CREATOR | Sofia Remedia, Cristina Martelli, Marcella Bonanomi, Bruno Giovanni Galuzzi, Francesca Servidio, Clarissa Gervasoni, Martina Nespoli, Chiara Pellizzer, Alessandro Giammona, Daniela Gaglio, Daniele Capitanio, Gloria Bertoli, Luisa Ottobrini, Alessia Lo Dico |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63270 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |