The relationship between renin-angiotensin system-modulating medication and depression: a systematic review
Sanika Kulkarni, Divya Prasad, Sarah Bauermeister, Andrea Reinecke · 2026
Read The relationship between renin-angiotensin system-modulating medication and depression: a systematic review by Sanika Kulkarni, Divya Prasad, Sarah Bauermeister, Andrea Reinecke (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13572380.txt.
Description
Sanika Kulkarni, with three colleagues, presents a 2026 review of whether blood pressure drugs that act on the renin-angiotensin system relate to depression. Two drug classes are in focus: ACE inhibitors and angiotensin receptor blockers. Lab work hints these drugs might lift mood, but human data have been mixed.
The team searched five databases for studies of adults, up to November 2024, and kept 15 studies with more than 7 million people in all. Eight studies linked the drugs to lower rates of depression, six found no clear link, and one found a small rise in major depression. Gains showed most in large registry studies that used doctor-coded diagnoses. The authors say varied methods and leftover bias bar firm claims, and they call for cleaner future studies.
Catalog record
| CREATOR | Sanika Kulkarni, Divya Prasad, Sarah Bauermeister, Andrea Reinecke |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 53024 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |