Metabolic reprogramming regulates macrophage polarization to impact ovarian cancer progression
Meng Zhang, Haizhou Fang, Shuangshuang Yang, Jinxi Yue, Lianlin Zeng, Hong Zhang · 2026
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Description
Meng Zhang and colleagues review, in a 2026 article, how the fuel choices of macrophages, the immune cells that crowd ovarian tumors, decide whether those cells attack the cancer or shelter it. Sugar burning, oxygen-based energy, and glutamine use each push macrophages toward one of two broad states, inflammatory or suppressive.
Tumor-associated macrophages mostly settle in the suppressive state, helping the cancer escape immunity and resist treatment. The review connects each metabolic pathway to that balance and surveys nanoscale delivery strategies that aim to reprogram macrophage fuel use precisely inside tumors. Ovarian cancer remains highly lethal, and retraining its resident immune cells offers a route that direct tumor drugs have not delivered.
Catalog record
| CREATOR | Meng Zhang, Haizhou Fang, Shuangshuang Yang, Jinxi Yue, Lianlin Zeng, Hong Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41188 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |