Tandem triplicate A29L peptide elicits robust immune responses against monkeypox virus in mice
Chia-Yu Liang, Ting-Yu Chang, Pei-Hsuan Chen, Tai-Ling Chao, Sui-Yuan Chang, Shih-Chung Chang · 2026
Read Tandem triplicate A29L peptide elicits robust immune responses against monkeypox virus in mice by Chia-Yu Liang, Ting-Yu Chang, Pei-Hsuan Chen, Tai-Ling Chao, Sui-Yuan Chang, Shih-Chung Chang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13572357.txt.
Description
Chia-Yu Liang and colleagues engineer, in a 2026 mouse study, a triple-repeat peptide vaccine against monkeypox virus. The vaccine is built from the first thirty-four building blocks of A29L, a surface protein the virus uses to attach and enter cells. That short stretch carries the patch neutralizing antibodies target, and repeating it three times was meant to strengthen the immune signal.
Vaccinated mice made antibody levels matching those from the full protein. Their serum recognized the target patch and neutralized live virus in cell tests, while immune cell responses leaned toward the virus-fighting type with strong interferon output. A safe subunit fragment that performs like the whole protein gives vaccine designers a compact blueprint.
Catalog record
| CREATOR | Chia-Yu Liang, Ting-Yu Chang, Pei-Hsuan Chen, Tai-Ling Chao, Sui-Yuan Chang, Shih-Chung Chang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32605 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |