Physical interaction with Ephrin B1 promotes CXCR4 intracellular localization and oncogenic potential
Alessandro Rabbito, Omolade Otun, Amos Fumagalli, Ana Alonso Bartolomé, Sonya Galant, Martial Séveno, Manuel Counson, Thierry Durroux, Cherine Bechara, Martine J Smit, Sébastien Granier, Martyna Szpakowska, Andy Chevigné, Séverine Chaumont-Dubel, Philippe Marin · 2026
Read Physical interaction with Ephrin B1 promotes CXCR4 intracellular localization and oncogenic potential by Alessandro Rabbito, Omolade Otun, Amos Fumagalli, Ana Alonso Bartolomé, Sonya Galant, Martial Séveno, Manuel Counson, Thierry Durroux, Cherine Bechara, Martine J Smit, Sébastien Granier, Martyna Szpakowska, Andy Chevigné, Séverine Chaumont-Dubel, Philippe Marin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13572348.txt.
Description
Alessandro Rabbito and a large team characterize, in a 2026 study, an unexpected partnership between CXCR4 and Ephrin B1. CXCR4 is a chemokine receptor that helps cancer cells move and grow. Ephrin B1 is a surface protein with similar jobs. A fishing method that purifies the receptor with its companions found Ephrin B1 as its most abundant partner.
The two proteins bind directly, more strongly once the receptor is activated. Ephrin B1 keeps the receptor off the cell surface by blocking its sugar decoration, dampening its usual surface signaling. It also routes signals inward that lower a death receptor on cancer cells. The split behavior marks Ephrin B1 as a possible lever on the receptor's tumor-driving indoor activity.
Catalog record
| CREATOR | Alessandro Rabbito, Omolade Otun, Amos Fumagalli, Ana Alonso Bartolomé, Sonya Galant, Martial Séveno, Manuel Counson, Thierry Durroux, Cherine Bechara, Martine J Smit, Sébastien Granier, Martyna Szpakowska, Andy Chevigné, Séverine Chaumont-Dubel, Philippe Marin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67214 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |