Integrated Multi-omics Profiling of 2,4-dinitrochlorobenzene (DNCB)-induced Atopic Dermatitis in Mice Reveals a Coordinated Network of Barrier Dysfunction, Immune Activation, and Metabolic Reprogramming
Wenxiang Liu, Xu Li, Zhihui Wan, Jieshi Xie, Shu Wang, Yanhong Zhai, Zheng Cao, Ping Wang, Cheng Wang · 2026
Read Integrated Multi-omics Profiling of 2,4-dinitrochlorobenzene (DNCB)-induced Atopic Dermatitis in Mice Reveals a Coordinated Network of Barrier Dysfunction, Immune Activation, and Metabolic Reprogramming by Wenxiang Liu, Xu Li, Zhihui Wan, Jieshi Xie, Shu Wang, Yanhong Zhai, Zheng Cao, Ping Wang, Cheng Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13572339.txt.
Description
Wenxiang Liu and colleagues profile, in a 2026 multi-omics study, mouse skin inflamed by a chemical that mimics atopic dermatitis, the eczema driven by a leaky skin barrier plus immune imbalance. Gene, protein, and metabolite layers were measured together and woven into networks to find changes that agree across all three.
Inflamed skin thickened and filled with T cells, macrophages, and mast cells. Barrier building programs broke down across layers, with two molecules, FLG2 and KRT6B, sitting at the network center. Energy and fat-handling pathways shifted in step with barrier genes. The coordinated map gives eczema researchers shared targets where barrier repair and metabolic correction might meet.
Catalog record
| CREATOR | Wenxiang Liu, Xu Li, Zhihui Wan, Jieshi Xie, Shu Wang, Yanhong Zhai, Zheng Cao, Ping Wang, Cheng Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51499 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |