Longitudinal plasma neurofilament light chain and patient-reported outcomes as complementary markers of vincristine-associated peripheral neuropathy in adults with lymphoma: a cohort study
Gretchen A McNally, Grace Ji-eun Shin, Lise Worthen-Chaudhari, Patrick M Schnell, Laura Flora, Surith Sanjay Krishna, Tim Voorhees, Robert Baiocchi, David Bond, Beth Christian, Kami Maddocks, Yazeed Sawalha, Maryam B Lustberg · 2026
Read Longitudinal plasma neurofilament light chain and patient-reported outcomes as complementary markers of vincristine-associated peripheral neuropathy in adults with lymphoma: a cohort study by Gretchen A McNally, Grace Ji-eun Shin, Lise Worthen-Chaudhari, Patrick M Schnell, Laura Flora, Surith Sanjay Krishna, Tim Voorhees, Robert Baiocchi, David Bond, Beth Christian, Kami Maddocks, Yazeed Sawalha, Maryam B Lustberg (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13572337.txt.
Description
Gretchen McNally and co-authors track in 2026 whether a blood marker of nerve injury matches patient reports in tracking chemo-induced neuropathy in lymphoma care. The drug vincristine often damages peripheral nerves, and options to detect or treat that harm are limited. The marker, neurofilament light chain, leaks from injured axons.
Twenty-five adults on first-line vincristine regimens are followed through four to six months of treatment. Blood draws at each cycle pair with patient and clinician neuropathy ratings. A small group is tracked for two to three and a half years after treatment. Marker levels rise relative to baseline as treatment proceeds. The study tests how closely blood and felt experience move together for monitoring.
Catalog record
| CREATOR | Gretchen A McNally, Grace Ji-eun Shin, Lise Worthen-Chaudhari, Patrick M Schnell, Laura Flora, Surith Sanjay Krishna, Tim Voorhees, Robert Baiocchi, David Bond, Beth Christian, Kami Maddocks, Yazeed Sawalha, Maryam B Lustberg |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |