A Review of Senescence‐Associated Secretory Phenotype‐Mediated Remodeling of the Tumor Microenvironment: Implications for Cancer Progression and Therapy
Sneha Pallatt, Sibin Nambidi, Antara Banerjee, Surajit Pathak · 2026
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Description
Sneha Pallatt, Sibin Nambidi, Antara Banerjee, and Surajit Pathak review how aged cells reshape the tissue around tumors. When cells senesce, they stop dividing but stay active, pouring out a mix of signals called SASP. That mix holds growth factors, immune lures, and enzymes that chew through tissue scaffolding. Their 2026 review gathers evidence on how SASP is switched on and how its effects flip with context: it can help immune cells clear tumors, or feed growth and spread.
The review then covers strategies that kill senescent cells or mute their signals. Such drugs could join cancer care if the timing is right. The authors stress that the same signals protect and harm, so blunt blocking is risky. Their map is aimed at researchers designing the next trials.
Catalog record
| CREATOR | Sneha Pallatt, Sibin Nambidi, Antara Banerjee, Surajit Pathak |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 109 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |