Valproic acid remodels phosphatidylglycerol homeostasis and epithelial-macrophage crosstalk in inflammatory signaling
Ivana Ďurišová, Mariana Máčajová, Ingrid Zriniová, Ivana Fábryová, Mailinda Meta, Lenka Bábelová, Boris Bilčík, Aleš Kvasnička, Miroslav Baláž, Soňa Bernátová, Silvia Petrezsélyová, Dominik Filipp, Yuan-Hao Hsu, David Friedecký, Ivan Čavarga, Mária Balážová · 2026
Read Valproic acid remodels phosphatidylglycerol homeostasis and epithelial-macrophage crosstalk in inflammatory signaling by Ivana Ďurišová, Mariana Máčajová, Ingrid Zriniová, Ivana Fábryová, Mailinda Meta, Lenka Bábelová, Boris Bilčík, Aleš Kvasnička, Miroslav Baláž, Soňa Bernátová, Silvia Petrezsélyová, Dominik Filipp, Yuan-Hao Hsu, David Friedecký, Ivan Čavarga, Mária Balážová (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13571955.txt.
Description
Ivana Ďurišová and co-authors study how a common epilepsy drug reshapes fats that calm lung inflammation, in a paper from 2026. Lung surface fats help keep airways calm and guard against germs. One such fat is built inside cell power plants, and its supply chain was unclear. The team broke a key building gene in lung cells and watched the fat profile shift.
The drug, valproic acid, changed the fats the cells shed and raised one calming fat in particular. Bathing immune cells in fluid from treated lung cells dulled their alarm response. Fat extracts alone carried part of that effect. In a living membrane model, both the drug and the fat kept tissue sound under attack. The work links inner fat making to how lungs talk to immune cells.
Catalog record
| CREATOR | Ivana Ďurišová, Mariana Máčajová, Ingrid Zriniová, Ivana Fábryová, Mailinda Meta, Lenka Bábelová, Boris Bilčík, Aleš Kvasnička, Miroslav Baláž, Soňa Bernátová, Silvia Petrezsélyová, Dominik Filipp, Yuan-Hao Hsu, David Friedecký, Ivan Čavarga, Mária Balážová |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |