CXCR4+ circulating tumor cells (CTCs) accumulate in subcutaneous, immune suppressive, CXCL12-loaded-hydrogel
Luigi Portella, Dario Guido Di Febbraro, Dario Righelli, Giulia Bertolini, Giuseppe Guardascione, Giuseppina Rea, Crescenzo D'Alterio, Caterina Ieranò, Sara Santagata, Anna Maria Trotta, Marco Gentili, Roberta Sulsenti, Antonio Luciano, Giuseppe Palma, Francesca Bruzzese, Ilaria Assunta Parisi, Anto · 2026
Read CXCR4+ circulating tumor cells (CTCs) accumulate in subcutaneous, immune suppressive, CXCL12-loaded-hydrogel by Luigi Portella, Dario Guido Di Febbraro, Dario Righelli, Giulia Bertolini, Giuseppe Guardascione, Giuseppina Rea, Crescenzo D'Alterio, Caterina Ieranò, Sara Santagata, Anna Maria Trotta, Marco Gentili, Roberta Sulsenti, Antonio Luciano, Giuseppe Palma, Francesca Bruzzese, Ilaria Assunta Parisi, Anto (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13571937.txt.
Description
Luigi Portella and a large team built a living trap for wandering cancer cells. Cells that break away from a tumor and ride the blood can seed new growths. Some of them home in on a signal molecule called CXCL12. The team loaded that signal into a soft gel placed under the skin, hoping to lure the cells away from organs they would otherwise colonize.
In dishes, cancer cells drawn into the gel switched on invasion and stem-like programs. In mice, the gel pulled in labeled lung cancer cells within hours and kept lung colonization down for three weeks. The gel's neighborhood turned suppressive to the immune system, with macrophage and neutrophil patterns shifting over time. The authors propose such traps could divert metastatic cells to a harmless site that doctors control.
Catalog record
| CREATOR | Luigi Portella, Dario Guido Di Febbraro, Dario Righelli, Giulia Bertolini, Giuseppe Guardascione, Giuseppina Rea, Crescenzo D'Alterio, Caterina Ieranò, Sara Santagata, Anna Maria Trotta, Marco Gentili, Roberta Sulsenti, Antonio Luciano, Giuseppe Palma, Francesca Bruzzese, Ilaria Assunta Parisi, Anto |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |