Skin organoid-derived exosomes in a hydrogel system potentiate skin wound healing
Tao Yang, Wen Zheng, Yue Li, Yingshi Li, Zhuxian Wang, Qiuyu Chen, Yangmeihui Wang, Xiaoye Shi, Jun Liu, Bin Yang · 2026
Read Skin organoid-derived exosomes in a hydrogel system potentiate skin wound healing by Tao Yang, Wen Zheng, Yue Li, Yingshi Li, Zhuxian Wang, Qiuyu Chen, Yangmeihui Wang, Xiaoye Shi, Jun Liu, Bin Yang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13571936.txt.
Description
Tao Yang and nine co-authors grow tiny skin organoids, harvest their exosomes, and set them in a gel to heal wounds. Their 2026 study notes that stem cell exosomes promise cell-free therapy but wash away fast and lack tissue-specific signals. Skin organoids, grown from human embryonic stem cells, mimic real skin's mixed cell community, so their exosomes carry skin-flavored messages.
The polyvinyl alcohol and gelatin gel heals itself, sticks well, and releases its cargo in a burst then a slow tail. In dishes the loaded gel beat plain exosome preparations at growing blood vessel cells and collagen output. In rat wounds it sped closure, vessel growth, and collagen deposition. One enriched microRNA, miR-125b-5p, was traced to the effect through the Wnt pathway. The authors pitch tissue-matched exosomes as the upgrade.
Catalog record
| CREATOR | Tao Yang, Wen Zheng, Yue Li, Yingshi Li, Zhuxian Wang, Qiuyu Chen, Yangmeihui Wang, Xiaoye Shi, Jun Liu, Bin Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |