Efficacy and safety of tiotropium in partial and uncontrolled preschool asthma (TIPP): a phase III, multicentre, randomised, double-blind, placebo-controlled trial
Stefan Zielen, Nadine Wollscheid, Tanja Nickolay, Caroline Grimmel, David Scheele, Franziska Sattler, Freerk Prenzel, Michael Lorenz, Bianca Schaub, Christiane Lex, Franziska Stieglitz, Jordis Trischler, Helena Donath, Susanne Lau, Eckard Hamelmann, Christian Vogelberg, Michael Gerstlauer, Ruth Gryc · 2026
Read Efficacy and safety of tiotropium in partial and uncontrolled preschool asthma (TIPP): a phase III, multicentre, randomised, double-blind, placebo-controlled trial by Stefan Zielen, Nadine Wollscheid, Tanja Nickolay, Caroline Grimmel, David Scheele, Franziska Sattler, Freerk Prenzel, Michael Lorenz, Bianca Schaub, Christiane Lex, Franziska Stieglitz, Jordis Trischler, Helena Donath, Susanne Lau, Eckard Hamelmann, Christian Vogelberg, Michael Gerstlauer, Ruth Gryc (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13571877.txt.
Description
Stefan Zielen and co-authors ran a large trial of an inhaled drug, tiotropium, as an add-on for preschool children whose asthma was only partly controlled. Young children face a higher risk of sudden, life-threatening breathing attacks than older children, and their treatment options are few. All children in the trial also used standard inhaled steroids.
The trial ran at thirteen centers in Germany with a double-blind, dummy-drug design, the strongest setup for fair comparison. Children were assigned at random to the add-on drug or a placebo spray. The study measured both how well the drug controlled asthma and how safe it was in this young age group. Results could widen the choices for families of children under six with hard asthma.
Catalog record
| CREATOR | Stefan Zielen, Nadine Wollscheid, Tanja Nickolay, Caroline Grimmel, David Scheele, Franziska Sattler, Freerk Prenzel, Michael Lorenz, Bianca Schaub, Christiane Lex, Franziska Stieglitz, Jordis Trischler, Helena Donath, Susanne Lau, Eckard Hamelmann, Christian Vogelberg, Michael Gerstlauer, Ruth Gryc |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |