Systemic Everolimus Does Not Block the Incubation of Methamphetamine‐Craving: A Dose–Response Study
Fernando J Cano, Kierra E Smith, Katherine Stuemke, Asha Jotwani, Erin Lassers, Holly M Nelson, Sonya D Adler, Laura L Huerta Sanchez, Christopher J E Denning, Samantha M Davantes, Citlali A Ibarra, Tod E Kippin, Karen K Szumlinski · 2026
Read Systemic Everolimus Does Not Block the Incubation of Methamphetamine‐Craving: A Dose–Response Study by Fernando J Cano, Kierra E Smith, Katherine Stuemke, Asha Jotwani, Erin Lassers, Holly M Nelson, Sonya D Adler, Laura L Huerta Sanchez, Christopher J E Denning, Samantha M Davantes, Citlali A Ibarra, Tod E Kippin, Karen K Szumlinski (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13571856.txt.
Description
Drug craving that grows during abstinence, called incubation, may share a common brain switch across drugs, and one lab found that switch in a signaling pathway for cocaine and sugar. Fernando Cano and co-authors asked in 2026 whether the same switch drives methamphetamine craving. Rats of both sexes self-administered the drug for ten days, then waited a month while craving incubated.
A drug that blocks the pathway, everolimus, had stopped cocaine and sucrose craving before. Here it did nothing at either dose, and the pathway showed no rise in the relevant brain regions. The authors conclude that methamphetamine's incubated craving runs on different machinery, so treatments may need to be drug-specific after all.
Catalog record
| CREATOR | Fernando J Cano, Kierra E Smith, Katherine Stuemke, Asha Jotwani, Erin Lassers, Holly M Nelson, Sonya D Adler, Laura L Huerta Sanchez, Christopher J E Denning, Samantha M Davantes, Citlali A Ibarra, Tod E Kippin, Karen K Szumlinski |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |