Adipose-derived extracellular vesicles miR-423-5p targets SMAD3 to reverse endometrial fibrosis in a porcine model of intrauterine adhesion: insights from single-cell sequencing
Xiao Xu, Xiaomin Wang, Quan Tian, Junlin Lv, Nailong Pan, Zhen Shang, Yiwei Xu, Xiaotong Li, Xiaoyan Li, Teng Wang, Yanjun Liu, Liang Zhang, Xiaoying Kong, Xiaodan Hao, Dan Han, Wenhua Xu · 2026
Read Adipose-derived extracellular vesicles miR-423-5p targets SMAD3 to reverse endometrial fibrosis in a porcine model of intrauterine adhesion: insights from single-cell sequencing by Xiao Xu, Xiaomin Wang, Quan Tian, Junlin Lv, Nailong Pan, Zhen Shang, Yiwei Xu, Xiaotong Li, Xiaoyan Li, Teng Wang, Yanjun Liu, Liang Zhang, Xiaoying Kong, Xiaodan Hao, Dan Han, Wenhua Xu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13571722.txt.
Description
Xiao Xu and co-authors test a cell-based gel treatment for scarring inside the womb, in a 2026 study. Such scarring, called intrauterine adhesion, is a fibrotic cause of infertility in women. Surgery often fails because the scars return. Tiny packets released by stem cells have shown promise in small animals, but they wash out fast and lack large-animal proof. The team loaded the packets into a gel that sets with body heat.
Pigs served as the test model, a first for this approach. The gel treatment cut scarring, rebuilt the womb lining, and grew new blood vessels. Single-cell gene reads showed the packets calm the cell groups that drive fibrosis. One small RNA inside the packets proved key, as it blocks a central scarring signal. The authors say the pair forms a target for future human therapy.
Catalog record
| CREATOR | Xiao Xu, Xiaomin Wang, Quan Tian, Junlin Lv, Nailong Pan, Zhen Shang, Yiwei Xu, Xiaotong Li, Xiaoyan Li, Teng Wang, Yanjun Liu, Liang Zhang, Xiaoying Kong, Xiaodan Hao, Dan Han, Wenhua Xu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |