ITGBL1 and RPN1 Mark a Fibrotic NP Subpopulation with Coupled Integrin Signaling and N-Glycosylation Programs in IVDD
Shuo Qiang, Yunke Liu, Yonghui Dong, Cheng Cheng, Yifan Huang, Jia Zheng, Chao Tang, Siyu Zhao · 2026
Read ITGBL1 and RPN1 Mark a Fibrotic NP Subpopulation with Coupled Integrin Signaling and N-Glycosylation Programs in IVDD by Shuo Qiang, Yunke Liu, Yonghui Dong, Cheng Cheng, Yifan Huang, Jia Zheng, Chao Tang, Siyu Zhao (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13571680.txt.
Description
Shuo Qiang and co-authors pinpoint a fibrotic cell subpopulation in degenerating spinal discs in a 2026 study. Disc degeneration brings pain and disability, and one cell subtype drives its scarring, yet that subtype's markers were unmapped. Two genes kept surfacing in bulk studies without a known home.
Machine learning over eighty-one bulk profiles nominated the pair, and single-cell data from two cohorts located them in the fibrotic subpopulation. The two programs they mark, integrin signaling and protein glycosylation, run coupled in those cells. Immune crosstalk and drug predictions were explored too. Naming the culprit cells gives disc research a target finer than the whole tissue.
Catalog record
| CREATOR | Shuo Qiang, Yunke Liu, Yonghui Dong, Cheng Cheng, Yifan Huang, Jia Zheng, Chao Tang, Siyu Zhao |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 77 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |