Altered striatal long-term potentiation in the eIF4E-TG mouse model of autism spectrum disorder
Alina Aaltonen, Jone Razquin, Daniel R. Garton, Julia Oyrer, Chiara Criscuolo, Ori J. Lieberman, Eric Klann, Anders Borgkvist, Emanuela Santini · 2026
Read Altered striatal long-term potentiation in the eIF4E-TG mouse model of autism spectrum disorder by Alina Aaltonen, Jone Razquin, Daniel R. Garton, Julia Oyrer, Chiara Criscuolo, Ori J. Lieberman, Eric Klann, Anders Borgkvist, Emanuela Santini (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13571666.txt.
Description
Alina Aaltonen, Jone Razquin, Daniel Garton, and a wider team wrote this research paper, published in 2026. It studies how a gene tied to autism risk changes the way neurons in the striatum, a deep brain area for habits and movement, strengthen their connections.
The gene, eIF4E, controls how cells build proteins, and mice engineered to make too much of it show autism-like behavior. In these mice, the team found denser spines on key striatal neurons and busier background signaling between cells. A form of connection strengthening that depends on NMDA receptors turned on more easily and grew larger. Blocking dopamine receptors did not stop the effect, which is unusual. Calcium signals inside the cells also shifted. The authors say the gene tilts striatal circuits toward one kind of plasticity, a clue to the biology of autism.
Catalog record
| CREATOR | Alina Aaltonen, Jone Razquin, Daniel R. Garton, Julia Oyrer, Chiara Criscuolo, Ori J. Lieberman, Eric Klann, Anders Borgkvist, Emanuela Santini |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 84 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |