Self-rolling film for in vivo drug delivery to limit colonic inflammation induced after radiation exposure
Diego Amarante-Silva, Christelle Demarquay, Benjamin Nottelet, Mathilde Grosjean, Sidzigui Ouedraogo, Fabien Milliat, Karine Anselme, Arnaud Ponche, Noëlle Mathieu · 2026
Read Self-rolling film for in vivo drug delivery to limit colonic inflammation induced after radiation exposure by Diego Amarante-Silva, Christelle Demarquay, Benjamin Nottelet, Mathilde Grosjean, Sidzigui Ouedraogo, Fabien Milliat, Karine Anselme, Arnaud Ponche, Noëlle Mathieu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13571658.txt.
Description
Diego Amarante-Silva and co-authors build a self-rolling film that delivers anti-inflammatory medicine straight to a radiation-injured colon. Radiation therapy saves cancer patients, yet it can inflame nearby healthy bowel, and systemic drugs expose the whole body. A local, gentle delivery route could calm the injury where it sits.
First they built a rat model of radiation proctitis with targeted, split-dose irradiation and full tissue checks. Then they engineered a two-layer PEG-PLA film, loaded with prednisolone, that curls into place through an endoscope. Placed in the injured bowel, the film cut inflammatory signals such as IL-1β. Local dosing like this may spare patients wider side effects.
Catalog record
| CREATOR | Diego Amarante-Silva, Christelle Demarquay, Benjamin Nottelet, Mathilde Grosjean, Sidzigui Ouedraogo, Fabien Milliat, Karine Anselme, Arnaud Ponche, Noëlle Mathieu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 48 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |