The Role of Mitochondrial Dysfunction in Hepatocellular Carcinoma: From Pathogenesis and Drug Resistance to Targeted Therapeutic Strategies
Siyu Zhao, Qian Liu, Jing Li, Shilei Zhang, Shuo Wan, Yuan Yang, Feng Jin, Biguang Tuo, Hai Jin · 2026
Read The Role of Mitochondrial Dysfunction in Hepatocellular Carcinoma: From Pathogenesis and Drug Resistance to Targeted Therapeutic Strategies by Siyu Zhao, Qian Liu, Jing Li, Shilei Zhang, Shuo Wan, Yuan Yang, Feng Jin, Biguang Tuo, Hai Jin (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13571629.txt.
Description
Siyu Zhao and co-authors review in a 2026 article how broken power plants inside cells drive liver cancer and blunt its drugs. The power plants, mitochondria, sit at the core of the cancer's start and spread. The review draws four routes: faulty energy burn with mutated plant DNA, a shift to glutamine fuel, stress from reactive oxygen, and a derailed cell-death path.
Drug resistance, they argue, flows from the same source: tumor cells flex their power plants to dodge attack. Fixes range from drugs that tune the burn to carriers that ferry drugs inside. Single fixes fade; combined ones, matched to each tumor's state, look stronger.
Catalog record
| CREATOR | Siyu Zhao, Qian Liu, Jing Li, Shilei Zhang, Shuo Wan, Yuan Yang, Feng Jin, Biguang Tuo, Hai Jin |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |