Nanoparticle-Based Therapeutic Strategies for Pathological Cardiac Hypertrophy: Preclinical Advances, Translational Challenges, and Future Perspectives
Mengyue Yang, Jinhui Wu · 2026
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Description
Mengyue Yang and Jinhui Wu review tiny carriers that ferry drugs to an overgrown heart. Pathological cardiac hypertrophy thickens the heart wall and paves the road to heart failure. Plain drugs spread through the whole body, so the heart gets a weak dose while other organs take the side effects. Their 2026 review sorts nanoparticle plans built to fix that spread.
Carrier types span mineral, organic, and body-mimicking shells. Targeting tricks range from passive drift to active homing and timed release. Routes of giving the dose run from vein shots to oral pills. Lab work covers gene fixes, anti-inflammatory loads, and scar softeners. The pair also weigh what blocks the jump from lab wins to clinic use.
Catalog record
| CREATOR | Mengyue Yang, Jinhui Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 113 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |