SFL-3D-cultured adipose mesenchymal cell-derived extracellular vesicles promote diabetic wound healing by alleviating microvascular endothelial senescence via PI3K/AKT/mTOR/4EBP1-mediated cap-dependent translation
Yunwei Wang, Zhihan Hu, Ao Shi, Peng Cao, Luyang Zhao, Xiaoyu Di, Yuchen Kang, Jiatong Wang, Li Gong, Wenjiao Chen, Gang Wang, Guangtong Cao, Liang Luo, Ruomei Zhao, Xi Zhang, Yi Liu · 2026
Read SFL-3D-cultured adipose mesenchymal cell-derived extracellular vesicles promote diabetic wound healing by alleviating microvascular endothelial senescence via PI3K/AKT/mTOR/4EBP1-mediated cap-dependent translation by Yunwei Wang, Zhihan Hu, Ao Shi, Peng Cao, Luyang Zhao, Xiaoyu Di, Yuchen Kang, Jiatong Wang, Li Gong, Wenjiao Chen, Gang Wang, Guangtong Cao, Liang Luo, Ruomei Zhao, Xi Zhang, Yi Liu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13571603.txt.
Description
Yunwei Wang and a large team test, in a 2026 study, tiny packages released by fat-derived stem cells grown in a three-dimensional self-feeder system as a treatment for diabetic wounds. The work centers on aging of the small blood vessel lining cells in skin, a driver of poor healing, rather than on generic vessel cells.
In dishes, the packages eased sugar-driven cell aging, oxidative stress, and mitochondrial trouble while restoring vessel growth, acting through a named signaling chain that controls protein production. Animal work covered both fat graft behavior and diabetic wound healing. Rejuvenating the microvascular lining, the study suggests, may unlock healing where current diabetic foot treatments stall.
Catalog record
| CREATOR | Yunwei Wang, Zhihan Hu, Ao Shi, Peng Cao, Luyang Zhao, Xiaoyu Di, Yuchen Kang, Jiatong Wang, Li Gong, Wenjiao Chen, Gang Wang, Guangtong Cao, Liang Luo, Ruomei Zhao, Xi Zhang, Yi Liu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 82682 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |