Sema3A Restores Bone Homeostasis in Peri-Implantitis by Activating Osteoblasts and Suppressing Osteoclasts via PI3K/AKT
Chenjiang He, Fang Dai, Jingting Wu, Libin Deng, Meixiu Jiang, Yuting Yang, Li Li, Fancheng Xu, Li Song · 2026
Read Sema3A Restores Bone Homeostasis in Peri-Implantitis by Activating Osteoblasts and Suppressing Osteoclasts via PI3K/AKT by Chenjiang He, Fang Dai, Jingting Wu, Libin Deng, Meixiu Jiang, Yuting Yang, Li Li, Fancheng Xu, Li Song (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13571595.txt.
Description
Chenjiang He and co-authors test a signaling protein as a shield against implant-related bone loss in a 2026 study. Peri-implantitis, inflammation around dental implants, dissolves the bone that anchors them and is a top cause of implant failure. The protein Sema3A is known to both build bone and restrain its breakdown.
In inflamed gum data and a mouse model, Sema3A levels fell as bone loss rose. In cell culture under bacterial challenge, boosting Sema3A restored the bone-building cells' growth and mineral work through a known growth pathway. In mixed cultures it also curbed the bone-eating cells, an indirect effect routed through the builders. Notably, extra Sema3A did nothing in calm conditions. The authors nominate it as a targeted therapy candidate.
Catalog record
| CREATOR | Chenjiang He, Fang Dai, Jingting Wu, Libin Deng, Meixiu Jiang, Yuting Yang, Li Li, Fancheng Xu, Li Song |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |