Cortical Hyperexcitability Shapes Large-Scale Brain Dynamics and Behavioral Outcome in Angelman Syndrome
Gian Marco Duma, Margherita Bagnoli, Giulia Stefanelli, Camille Mazzara, Giovanni Pellegrino, Giovanni Mento, Pierpaolo Sorrentino, Lisa Toffoli, Fiorella Del Popolo Cristaldi, Lisa Antoniazzi, Rebecca Azzolini, Jacopo Dei Tos, Martina Baggio, Paolo Bonanni, Alberto Danie · 2026
Read Cortical Hyperexcitability Shapes Large-Scale Brain Dynamics and Behavioral Outcome in Angelman Syndrome by Gian Marco Duma, Margherita Bagnoli, Giulia Stefanelli, Camille Mazzara, Giovanni Pellegrino, Giovanni Mento, Pierpaolo Sorrentino, Lisa Toffoli, Fiorella Del Popolo Cristaldi, Lisa Antoniazzi, Rebecca Azzolini, Jacopo Dei Tos, Martina Baggio, Paolo Bonanni, Alberto Danie (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13571587.txt.
Description
Gian Marco Duma and colleagues record, in a 2026 study, resting brain waves in twenty-nine people with Angelman syndrome and thirty-six controls. Angelman syndrome is a rare disorder caused by loss of one copy of a key gene. From the recordings they computed an excitability index for cortical regions and a fluidity index describing how unstable large-scale brain networks are over time.
Excitability ran high across several regions in Angelman syndrome, including frontal and rear areas, and network fluidity was greater across frequency bands, signaling less stable teamwork. The measures were also set against medical features and caregiver reports. A simple EEG readout of excitation imbalance could help track severity and test future treatments in this disorder.
Catalog record
| CREATOR | Gian Marco Duma, Margherita Bagnoli, Giulia Stefanelli, Camille Mazzara, Giovanni Pellegrino, Giovanni Mento, Pierpaolo Sorrentino, Lisa Toffoli, Fiorella Del Popolo Cristaldi, Lisa Antoniazzi, Rebecca Azzolini, Jacopo Dei Tos, Martina Baggio, Paolo Bonanni, Alberto Danie |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37285 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |