Integrative transcriptomics and human tibial artery validation identify ADAM12, PDK4, and RUNX1 as peripheral artery disease-associated genes enriched in calcified tibial arteries
Snow Adler, Jorge RuizdelRio, Brian Eliceiri, Ann C Gaffey · 2026
Read Integrative transcriptomics and human tibial artery validation identify ADAM12, PDK4, and RUNX1 as peripheral artery disease-associated genes enriched in calcified tibial arteries by Snow Adler, Jorge RuizdelRio, Brian Eliceiri, Ann C Gaffey (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13571584.txt.
Description
Snow Adler and colleagues hunt, in a 2026 study, for genes behind the chalky stiffening of shin arteries that blocks limb-saving treatment in peripheral artery disease. Public gene data from fourteen data sets comparing diseased and healthy tissue yielded eighty-nine differing genes. Fourteen candidates tied to vessel cell calcification were then checked in real human tibial arteries and cultured vessel cells.
Three genes stood out in diseased arteries taken during amputations, matching their ranking from the data screen. The differing genes clustered in inflammation, bone-like, and metabolic pathways. Naming concrete drivers gives drug researchers footholds against a calcification process that currently has no targeted treatment.
Catalog record
| CREATOR | Snow Adler, Jorge RuizdelRio, Brian Eliceiri, Ann C Gaffey |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |