Non-canonical activation of VEGFA through TIMM44-dependent mitochondrial remodelling
Tanvi Chaudhary, Sharath Mohan Bhat, Priyadarshika Pradhan, Manjunath B. Joshi, Devanjan Sinha · 2026
Read Non-canonical activation of VEGFA through TIMM44-dependent mitochondrial remodelling by Tanvi Chaudhary, Sharath Mohan Bhat, Priyadarshika Pradhan, Manjunath B. Joshi, Devanjan Sinha (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13571582.txt.
Description
Tanvi Chaudhary and four co-authors uncover an unexpected route by which mitochondria switch on a blood-vessel growth gene in tumor cells, in this 2026 paper. The gene, VEGFA, normally responds to low oxygen through a famous sensor pathway. Their story starts instead at the mitochondrial import machinery, the gates that pull proteins into the organelle.
One gate component, TIMM44, runs high in angiogenesis-driven tumors. Raising import capacity remodeled respiration without adding mitochondria. The altered redox state then fired a kinase chain, ASK1 to p38MAPK, ending with the transcription factor SP1 turning VEGFA on, no oxygen sensing involved. Forcing extra mitochondria through a biogenesis switch did not reproduce the effect, so import quality, not quantity, carries the signal. The authors frame protein import as an active signaling regulator linking organelle state to gene programs.
Catalog record
| CREATOR | Tanvi Chaudhary, Sharath Mohan Bhat, Priyadarshika Pradhan, Manjunath B. Joshi, Devanjan Sinha |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 80 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |