Haplotype-resolved 3D genome maps reveal RNAPII-mediated allelic regulation in hybrid rice
Shiping Luan, Runxin Gao, Guoting Chen, Chuanhao Liu, Denggao Li, Zhifei Xue, Ying Zhang, Yue Li, Cheng Ding, Beibei Liu, Yanyan Liu, Jiapei Yan, Mohamed F. Foda, Xingwang Li, Weizhi Ouyang · 2026
Read Haplotype-resolved 3D genome maps reveal RNAPII-mediated allelic regulation in hybrid rice by Shiping Luan, Runxin Gao, Guoting Chen, Chuanhao Liu, Denggao Li, Zhifei Xue, Ying Zhang, Yue Li, Cheng Ding, Beibei Liu, Yanyan Liu, Jiapei Yan, Mohamed F. Foda, Xingwang Li, Weizhi Ouyang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13571577.txt.
Description
Luan and co-authors build a three-dimensional genome map that keeps a hybrid rice plant's two parents separate. Their 2026 paper uses phased Bridge-Linker Hi-C on Shanyou 63, an elite hybrid line. The method resolves chromatin architecture per haplotype. The team adds allele-resolved maps of RNA polymerase II contacts and phased gene activity data.
The maternal and paternal genome copies shared broadly similar folding, but allele-specific differences were widespread. One haplotype often bound the transcription machinery more strongly and formed more long-range loops to distant genes. Those stronger contacts were significantly tied to biased expression of the corresponding gene copy, even where binding near the gene's start looked equal between copies. The authors conclude that subtle differences in how each parental genome engages the transcription machinery and wires its loops reshape which copy gets heard in hybrids.
Catalog record
| CREATOR | Shiping Luan, Runxin Gao, Guoting Chen, Chuanhao Liu, Denggao Li, Zhifei Xue, Ying Zhang, Yue Li, Cheng Ding, Beibei Liu, Yanyan Liu, Jiapei Yan, Mohamed F. Foda, Xingwang Li, Weizhi Ouyang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 51 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |