Evaluating the Whole Blood Survival Advantage: How Citrate and Calcium Levels Drive Mortality in a Translational Swine Model of Polytrauma

Jason M. Rall, Craig D. Nowadly, Jae-Hyek Choi, Heang Sundermann, Kaysie Sutton, Allyson A. Arana, Dena Norouzi, R. Madelaine Paredes, Joseph K. Maddry · 2026

Read Evaluating the Whole Blood Survival Advantage: How Citrate and Calcium Levels Drive Mortality in a Translational Swine Model of Polytrauma by Jason M. Rall, Craig D. Nowadly, Jae-Hyek Choi, Heang Sundermann, Kaysie Sutton, Allyson A. Arana, Dena Norouzi, R. Madelaine Paredes, Joseph K. Maddry (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13571567.txt.

Description

Jason Rall and co-authors test whole blood transfusion in a pig trauma model in a 2026 study. Thirty-two pigs received fracture, liver injury, and controlled blood loss. A thirty-minute shock period followed the injuries.

Whole blood is returning to trauma care, but survival results are mixed. Component therapy is the main alternative in hospitals. Citrate exposure from stored blood can drop calcium levels. The team tied citrate, calcium dosing, and stability to survival. Animals were assigned at random to transfusion plans. Readers learn which chemical details may decide whether whole blood saves or harms.

Catalog record

CREATORJason M. Rall, Craig D. Nowadly, Jae-Hyek Choi, Heang Sundermann, Kaysie Sutton, Allyson A. Arana, Dena Norouzi, R. Madelaine Paredes, Joseph K. Maddry
YEAR2026
COLLECTIONPAPERS
FORMATTXT
FILE SIZE41 KB
VERSION1.0
LICENSECC BY 4.0
RIGHTSCC BY
SOURCEEurope PMC

Source: https://europepmc.org/articles/PMC13571567

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