Peroxiredoxin-6 protects against oxidative stress-mediated hypertrophic remodeling in JPH2-A399S knock-in mice
Callum J Quinn, Satadru K Lahiri, Ann P Quick, Sören Brandenburg, Dennis Uhlenkamp, Antrix Jain, Lucia M Moreira, Sun Y Jung, Svetlana Reilly, Rana Sayeed, George Krasopoulos, Stephan E Lehnart, Xander HT Wehrens · 2026
Read Peroxiredoxin-6 protects against oxidative stress-mediated hypertrophic remodeling in JPH2-A399S knock-in mice by Callum J Quinn, Satadru K Lahiri, Ann P Quick, Sören Brandenburg, Dennis Uhlenkamp, Antrix Jain, Lucia M Moreira, Sun Y Jung, Svetlana Reilly, Rana Sayeed, George Krasopoulos, Stephan E Lehnart, Xander HT Wehrens (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13571560.txt.
Description
Callum Quinn and co-authors find an antioxidant shield behind a rare heart muscle disease in a 2026 paper. Most thick heart disease stems from sarcomere genes, but a variant in junctophilin-2 also causes it, by unclear means. A teen patient's variant is rebuilt in mice, which grow the same wall thickening. Protein fishing shows the mutant partner peroxiredoxin-6 drops in the thickened wall, and oxygen stress rises there.
A virus delivered boost of that protein reverses the thickening, they report. The same protein runs low in human failing hearts. The authors name oxidative stress, not calcium trouble, as the driver here, opening a fresh treatment angle.
Catalog record
| CREATOR | Callum J Quinn, Satadru K Lahiri, Ann P Quick, Sören Brandenburg, Dennis Uhlenkamp, Antrix Jain, Lucia M Moreira, Sun Y Jung, Svetlana Reilly, Rana Sayeed, George Krasopoulos, Stephan E Lehnart, Xander HT Wehrens |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 28 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |