Associations of Growth Differentiation Factor 15 in Chronic Kidney Disease
Thomas McDonnell, Samantha Hayward, Nicolas Vuilleumier, Moin A. Saleem, Philip A. Kalra, Maarten W. Taal · 2026
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Description
McDonnell and co-authors test a hormonal suspect in this 2026 cohort study of appetite loss in chronic kidney disease, a symptom affecting up to half of patients and tied to worse survival. The suspect is GDF-15, a stress cytokine known to suppress appetite in cancer. The cohort is NURTuRE-CKD, with 2,996 people who have kidney disease but are not yet on dialysis. They were followed for a median of fifty months.
GDF-15 was measured in 2,929 participants, and the 27 percent reporting poor appetite carried clearly higher levels, a median of 2,965 against 2,350 picograms per milliliter in the comparison. Each doubling of the hormone raised the odds of poor appetite by a factor of 1.44 in adjusted analysis, and it also tracked weaker grip strength and lower estimated muscle mass. Doubling predicted disease progression at a hazard ratio of 1.30 and death at 1.72 across follow-up, keeping the cancer appetite-drug analogy alive.
Catalog record
| CREATOR | Thomas McDonnell, Samantha Hayward, Nicolas Vuilleumier, Moin A. Saleem, Philip A. Kalra, Maarten W. Taal |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |